GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs16958440 | 1 | rs60422392 | chr18:44621473 | PIAS2 | chr18:44392061-44500123:- | -0.16 | -3.35 | 0.000869 | Sitting height ratio |
| THCA | cis | rs6042314 | 1 | rs6042314 | chr20:13696129 | C20orf7 | chr20:13765682-13797872:+ | -0.19 | -4.06 | 5.81E-5 | Intelligence (childhood) |
| THCA | cis | rs2120019 | 1 | rs60425110 | chr15:75333000 | ARID3B | chr15:74833548-74890470:+ | -0.16 | -3.91 | 0.000108 | Blood trace element (Zn levels) |
| THCA | cis | rs2120019 | 1 | rs60425110 | chr15:75333000 | PPCDC | chr15:75315927-75343066:+ | 0.19 | 5.1 | 5.02E-7 | Blood trace element (Zn levels) |
| THCA | cis | rs2120019 | 1 | rs60425110 | chr15:75333000 | SCAMP5 | chr15:75287901-75313836:+ | 0.51 | 8.64 | 8.69E-17 | Blood trace element (Zn levels) |
| THCA | cis | rs7216064 | 1 | rs60432293 | chr17:65860407 | C17orf58 | chr17:65987218-65989765:- | 0.24 | 4.89 | 1.41E-6 | Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma |
| THCA | cis | rs932541 | 1 | rs6043988 | chr20:16455165 | KIF16B | chr20:16252749-16554078:- | -0.16 | -3.77 | 0.000186 | Intelligence |
| THCA | cis | rs932541 | 1 | rs6043989 | chr20:16455389 | KIF16B | chr20:16252749-16554078:- | -0.16 | -3.77 | 0.000186 | Intelligence |
| THCA | cis | rs932541 | 1 | rs6043991 | chr20:16457369 | KIF16B | chr20:16252749-16554078:- | -0.16 | -3.77 | 0.000186 | Intelligence |
| THCA | cis | rs6044112 | 1 | rs6044111 | chr20:16536324 | KIF16B | chr20:16252749-16554078:- | 0.26 | 5.09 | 5.28E-7 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs6044112 | 1 | rs6044112 | chr20:16536414 | KIF16B | chr20:16252749-16554078:- | 0.26 | 5.04 | 6.52E-7 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs2129782 | 1 | rs60469280 | chr8:89452250 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs6047116 | 1 | rs6047116 | chr20:20848968 | RALGAPA2 | chr20:20373412-20693266:- | 0.11 | 4.09 | 4.99E-5 | Cognitive function |
| THCA | cis | rs2241437 | 1 | rs60479377 | chr2:86283948 | LOC90784 | chr2:86247339-86250991:- | -0.61 | -6.49 | 2.17E-10 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs9303029 | 1 | rs60482040 | chr17:80403059 | C17orf62 | chr17:80400520-80408694:- | -0.27 | -6.55 | 1.53E-10 | Protein quantitative trait loci |